Thanks guys so much for the response! I was in the middle of writing a response for to long and didn't notice.
The KB makes things clearer!
With this knowledge, it makes the issues we are experiencing even stranger.
We have two routes between one of our global locations. When we route traffic using route A, the publisher and subscriber see each other and replication occurs (albeit, slowly). When we route traffic using route B, the CPPM in our remote location loses contact with the Publisher CPPM. The two servers can ping each other, but to the subscriber the publisher is completely offline. The publisher though does not report the subscriber is down.
We tested to ensure routing and firewall rules are okay. Everything looks okay, but still the issue exists.
We are not using any load balancing anywhere. We have no VIP.
Sorry for not explaining myself properly.
In the case where, a publisher sends replicated data to the subscriber, that data would leave the management interface on the publisher and enter the subscriber on the subscribers management interface? Is this correct?