Yes. When that is enabled, all of the following will work:
username
username@domain.com
DOMAIN\username
HOST\computer-name.domain.com
The nice thing with UPNs is you can make policy decisions based on the authenticating user's domain. This is how eduroam works at its core. You can either do seperate services for each domain or just reference the "Authentication:Full-Username" attribute in a role map or enforcement policy.